Nonmyeloablative allogeneic hematopoietic stem-cell transplantation a new immunotherapy for solid tumor
- VernacularTitle:非清髓性异基因干细胞移植治疗实体瘤的研究进展
- Author:
Jian GENG
;
Longbang CHEN
- Publication Type:Journal Article
- Keywords:
Allogeneic hematopoietic stem-cell transplantation;
Nonmyeloablative pre-conditioning;
Graft-versus-tumor effect;
Solid tumor
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Based on the practive of traditional allogeneic hematopoietic stem-cell transplantation therapy allo-HSCT and the development of nonmyeloablative conditioning, a new immunotherapy for solid tumor nonmyeloablative allo-HSCT, has been initiated. The nonmyeloablative,preparative regimens are associated with the use of lower dose of drugs,and less treatment-related toxicities. Instead of achieving maximal tumor reduction, the regimens are disigned to induce adequate immunosuppression to permit the engraftment of donor hematopoietic stem cells and serve as the platform for the administration of donor T cell in adoptive cell therapy. Donor's T-cell mediates a graft-versus-tumor(GVT)effect. This response is effective for the eradication of acceptor's tumor cell. This article reviews the concept, rationale, early clinical results, and limitation of nonmyeloablative allo-HSCT as a novel immunotherapy in solid tumors.
