Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy.
- Author:
Young Suk KIM
1
;
Chang Geol LEE
;
Kyung Hwan KIM
;
Taehyung KIM
;
Joohwan LEE
;
Yona CHO
;
Woong Sub KOOM
Author Information
1. Department of Radiation Oncology, Yonsei University Health System, Yonsei University College of Medicine, Seoul, Korea. MDGOLD@yuhs.ac
- Publication Type:Original Article
- Keywords:
Esophageal cancer;
Neoplasm recurrence;
Re-irradiation;
Radiotherapy;
Chemotherapy;
Toxicity
- MeSH:
Deglutition Disorders;
Esophageal Neoplasms;
Follow-Up Studies;
Humans;
Tracheoesophageal Fistula
- From:Radiation Oncology Journal
2012;30(4):182-188
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. MATERIALS AND METHODS: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). RESULTS: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). CONCLUSION: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity.
