Association of TNF-? gene polymorphism with Graves′ ophthalmopathy
- VernacularTitle:肿瘤坏死因子基因多态性与Graves眼病的相关性研究
- Author:
Weiyan JIANG
;
Ling JIANG
;
Ying GONG
- Publication Type:Journal Article
- Keywords:
Tumour necrocisis factor;
Graves′ disease;
Graves′ ophthalmopathy;
Gene polymorpohism
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of tumour necrosis factor- ? (TNFs-?) gene polymorphism with Graves ophthalmopathy (GO)Chinese in Shandong . Methods: Allele and genotype frequencies were determined by polymerase chain reaction with sequence specific primers(PCR-SSP). Results: Allele and genotype frequencies of TNF-? +488、-308 were not different significantly between Graves′ disease(GD) and control, or GD subgroups with and without GO. There were also no significant differences between GO subgroups with different severity. Conclusion: There are no associations of TNF-? +488、–308 polymorphisms with GO susceptibility in Shandong Chinese.
