Effects of ?-melanocyte-stimulating hormone on TGF-?_1 secretion of fibroblasts from keloids
- VernacularTitle:?-促黑素细胞激素对瘢痕疙瘩成纤维细胞分泌转化生长因子-?1的影响
- Author:
Jiansheng ZHENG
;
Xin XING
;
Jingde ZHANG
- Publication Type:Journal Article
- Keywords:
MSH;
Keloid;
Fibroblast;
TGF-?_1
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of ?-melanocyte-stimulating hormone(?-MSH) on TGF-?_1 secretion of fibroblasts from keloids so as to find a novel evidence to research etiology of keloids.Methods:Fibroblasts isolated from human keloids were cultured in DMEM medium with 15% bovine serum and treated with ?-MSH. The level of TGF-?_1 was measured with ELISA method. Results: ?-MSH at the concentration of 10 -6 mmol/L triggered the TGF-?_1 secretion of fibroblasts. Conclusion:?-MSH possesses the effect of triggering human keloid fibroblasts to secrete TGF-?_1, and its effective concentration is 10 -6mmol/L.
