Function of osteopontin and its clinical relation with tumor
- VernacularTitle:骨桥蛋白与肿瘤
- Author:
Hongzhi ZHAO
;
Ping LIANG
- Publication Type:Journal Article
- Keywords:
Osteopontin;
Tumor;
Metastasis;
Angiogenesis
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Osteopontin (OPN), a phosphorylated and glycosylated protein, is a prominent matricellular component of the extracellular matrix of mineralized tissues of bones and teeth, in which they can regulate the formation and growth of hydroxyapatite crystals and influence a variety of cell activities. Recent studies have reported that the expression of OPN is not only correlated with bone formation and bone resorption but also with tumor aggression and metastasis in several types of human cancer, and OPN is even considered to be an index for the diagnosis and prognosis of tumor. The roles of OPN in angiogenesis were also reviewed.
