Anti-tumor effect of Haishengsu extracted from Tegillarca granosa in vitro and in vivo
- VernacularTitle:泥蚶提取物-海生素抗肿瘤作用的实验研究
- Author:
Ruyong YAO
;
Xiao CHU
;
Yujiang ZHANG
;
Xiu YANG
;
Xiurong LIU
;
Chunb WANG
- Publication Type:Journal Article
- Keywords:
Haishengsu;
Tegillarca granosa;
test of drug sensitive;
anti-tumor effect
- From:
Chinese Journal of Marine Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the infuences of Haishengsu extracted from Tegillarca granosa on cultured tumor cells of lung cancer, breast cancer and carcinoma of stomach from human in vitro and its preventive antitumor effect on transplanted tumor in mice in vivo. Methods The inhibitory effect of Haishengsu on tumor cells proliferation was assayed by MTT method, and transplant tumor models of sarcoma 180 (S 180), Ehrlich ascites carcinoma (EAC), and hepatoma (Heps) were used. Before and after transplantation, different doses of Haishengsu were given to the mice for 10 days. The inhibition rates and life span of the mice were calculated. Results Haishengsu at concentrations of 0.5%～2.0% inhibited the proliferation of tested tumor cells in vitro,especially on lung cancer cells with a dose dependent manner (r= 0.974,P
