The Expression of c-fos of Hippocampal Neurons in Morphine Dependent Mice
- VernacularTitle:吗啡依赖小鼠海马神经元c-fos的表达
- Author:
Jie WEI
;
Yinguo ZHANG
;
Jisheng LI
- Publication Type:Journal Article
- Keywords:
pathology morphine dependence animal studies rat Fos protein hippocampus
- From:
Chinese Mental Health Journal
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the difference of c-fos expression of neurons in subareas of hippocampus of morphine dependent mice.Methods:Mice were given (sc) increasing doses of morphine to form morphine dependent models and withdrawal syndromes were precipitated by naloxone. The intensity of withdrawal syndromes was evaluted accoding to indices ,such as the number of jumping ,the weight loss,et al .The expression of Fos positive neurons in subareas of CA1, dentate gyrus and CA3 of hippocampus of morphine dependent group was observed by immunohistochemistry assay. Results:The number of Fos positive cells in subareas of CA1 and dentate gyrus of morphine dependent group was much higher than that of the normal control group(P
