Discriminatory Potential of The Chinese version of ADAS-Cog for Mild versus Moderate Alzheimer Disease
- VernacularTitle:ADAS-Cog中文版区分轻、中度阿尔茨海默病的能力
- Author:
Xin YU
;
Huali WANG
;
Shuran LI
- Publication Type:Journal Article
- Keywords:
psychometric studies ADAS Chinese cognitive impairment
- From:
Chinese Mental Health Journal
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the discriminatory potential of the ADAS-Cog, Chinese version for mild and moderate Alzheimer's disease (AD). Methods:Patients with AD (199 mild AD and 106 moderate AD) meeting the NINCDS-ADRDA criteria of probable AD were recruited. The Chinese version of ADAS-Cog was administered to all AD subjects. Results:The total score of ADAS-Cog and the score of each ADAS-Cog item differed significant-ly between mild and moderate AD groups, with higher scores in moderate AD group. GLM analysis showed insignifi-cant influence of age or educational level on the ADAS-Cog total score. These results indicated that ADAS-Cog could represent the distinctive profiles of cognitive impairment between mild and moderate AD. The results of Logis-tic regression analysis showed that the item score of orientation and constructional praxis as well as the ADAS-Cog total score could classify mild and moderate AD efficiently, with a sensitivity of 78% - 82% and a specificity of 70% - 73%. Conclusion:Our results indicate that the Chinese version of ADAS-Cog is useful for staging of AD. It is recom-mended that the Chinese version of ADAS-Cog be introduced for monitoring the AD drug therapeutic efficacy on cognitive impairment among Chinese AD patients.psychiatry Alzheimer's disease
