Regulating Synthesis of Nitric Oxide in Progression of Atherosclerotic after 10-week Aerobic Training in ApoE-deficient Mice
- VernacularTitle:有氧运动改善ApoE基因缺陷小鼠NO合成抗AS机制的探讨
- Author:
Baisheng ZENG
;
Jing ZHANG
;
Ming FANG
- Publication Type:Journal Article
- Keywords:
aerobic training, ApoE-deficient, atherosclerosis, n itric oxide
- From:Chinese Journal of Sports Medicine
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to probe other possible mechanisms of aerobic tra ining in anti-atherosclerosis besides lipid-regulation, we observed the influenc e of aerobic training on the formation of atherosclerotic plaque, the concentrat ion of nitric oxide(NO) in serum, the content of inducible nitric oxidase (iN OS) and endothelial nitric oxidase (eNOS) in thoracic aorta in ApoE-deficient mi ce. Methods The atherosclerotic lesions, the serum NO, the con tent of thoracic aortic iNOS and eNOS by ABC immunohistochemical staining combin ed with computer image quantitative analysis technique on frozen sections were m easured after 10-week swimming training. Thoracic aorta Oil Red O (ORO) staining on the intima were als o analyzed. Results Compared with controls, aerobic training d elayed the plaque formation i n ApoE-deficient mice (P
