Molecular genetics analysis of a Chinese family carrying triple HLA-A antigen
- VernacularTitle:一个HLA-A抗原三联体家庭的分子遗传学研究
- Author:
Hui ZHANG
;
Wenying DI
;
Jian ZHANG
- Publication Type:Journal Article
- Keywords:
HLA triplet;
HLA haplotype;
Gene cloning;
Family study
- From:
Chinese Journal of Blood Transfusion
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective A rare HLA phenotype carrying three HLA-A antigens, A2, A11.2 and A24, was identified in a potential bone marrow donor SZHD1. Methods To determine molecular basis of this phenotype the HLA-A gene fragments from this donor and his family members were cloned and sequenced. Results Sequencing analysis indicated that the donor carries an unusual HLA haplotype, A*1102, A*24020101; B*38; DRB1*15. Conclusions Other four family members were found to carry this haplotype, which as a Mendelian gene was segregated and stably transmitted through three generations. This is a first example of a family carrying triple HLA-A antigens to the best of our knowledge.
