Tumor-targeting carrier equipped with cell-penetrating peptides
10.3872/j.issn.1007-385X.2010.01.021
- VernacularTitle:联合细胞穿膜肽的肿瘤靶向载体
- Author:
Weijie SHI
;
Liwei BI
;
Ruian XU
- Publication Type:Journal Article
- Keywords:
cell-penetrating peptide;
tumor therapy;
targeting carrier
- From:
Chinese Journal of Cancer Biotherapy
2010;17(1):104-108,114
- CountryChina
- Language:Chinese
-
Abstract:
Equipping tumor-targeting carrier with cell-penetrating peptide with high transduction efficacy has become a trend. According to the fusion modes and tumor-targeting mechanisms, cell-penetrating peptides can be divided into five categories: first, self-targeting cell-penetrating peptides; second, fusion carriers made of targeting ligands and cell-penetrating peptides; third, cell-penetrating peptide-modified nano-carrier; fourth, tumor-microenvironment-targeting cell-penetrating peptides; fifth, other special cell-penetrating peptides. Fusion carriers, which can not be effectively released into the cytoplasm after transducted into target cells, can be further modified to increase their efficacy. In all, cell-penetrating peptide introduced into tumor-targeting carrier should provide a new era for anti-tumor pharmacy research and cancer therapy.
