Effects of orphanin FQ on endomorphin-1 induced antinociception
- VernacularTitle:孤啡肽对内吗啡肽-1抗伤害感受作用的影响
- Author:
Ren GUAN
;
Weiyan LI
;
Jianguo XU
;
Ya DING
- Publication Type:Journal Article
- Keywords:
Orphanin FQ;
Endomorphin-1;
Antinociceptive effect
- From:
Journal of Medical Postgraduates
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of OFQ on endomorphin-1 in pain modulation. Methods: OFQ and endomorphin-1 were microinjected intracerebroventricularly or intrathecally in rats. The pain thresholds were measured by tail-flick test and acetic-acid induced twitching test, and the changes of antinociceptive effects induced by endomorphin-1 were observed. Results: OFQ antagonizing endomorphin-1 antinociception at the supraspinal level, while enhancing at the spinal level were observed. Conclusion: OFQ has functional effects on endomorphin-1 in pain modulation,both in the brain and the spinal cord. The mechanisms of its effect may be different.
