Progress in building animal model of irritable bowel syndrome
- VernacularTitle:肠易激综合征动物模型研究进展
- Author:
Junrong XU
;
Jinyan LUO
- Publication Type:Journal Article
- Keywords:
IBS;
animal;
model
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Irritable Bowel Syndrome(IBS) is a common disease of intestinal disorder.It is characterized by chronic or recurrent abdominal pain or discomfort along with altered bowel function.The underlying mechanisms of IBS remain unclear.Several studies showed that the attack of IBS might be related to the gastrointestinal motility,visceral hypersensitivity,infection of the bowel and several other factors.Existing animal models can be divided into 2 broad categories based on their primary pathogenetic mechanisms: those initiated by a central nervous system-directed(psychosocial) stressor and those stems from a gut-directed stressor(gut inflammation,infection).This article reviews the current research of IBS animal model.
