Correlating signal transduction pathway of mammary epithelial stem cells to breast cancer
- VernacularTitle:乳腺干细胞的信号传导通路与乳腺癌
- Author:
Xiaodong ZHU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Mammary epithelial stem cells, a kind of adult stem cells, possess the potential of multiple differentiation and self-renewal. Studies on mammary epithelial stem cells provide theoretical foundation for mammary gland reconstruction and for preventing and treating breast cancer. Generally, differentiation and renewal of mammary epithelial stem cells are strictly regulated by signal transduction pathway and hormone. Once this mechanism is destroyed or abnormally regulated, cells can abnormally differentiate, unconditionally grow, proliferate, and resulting in mammary epithelial stem cells and tumor. Signal transduction pathway of mammary epithelial stem cell proliferation and differentiation including Wnt, Wnt/?-catenin, Notch and Hedgehog is associated with the onset of breast cancer. To understand the signal transduction pathway, regulatory mechanism and key molecule of self-renewal of mammary epithelial stem cells are crucial for designing an effective method of eradicating tumor initiator cells and mammary epithelial stem cells.
