Expression of COX-2 in acute spinal cord injury of rats
- VernacularTitle:实验性大鼠脊髓损伤后环氧化酶2的表达及意义
- Author:
Dongming ZHAO
;
Shiqing LIU
;
Liang CHEN
;
Zhongli ZHANG
- Publication Type:Journal Article
- Keywords:
Spinal cord injury;
COX-2;
Inflammation
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes in the expression of COX-2 in acute spinal cord injury of rats. Methods:Sixty adult SD rats were randomly divided into two groups: Trauma group (n=48) subjected to laminectomy and bounce of spinal cord; control group (n=12) only received laminectomy. The activity of COX-2 was detected using immunohistochemistry and Western blot analysis in cytoplasm of spinal cord. Results:The expression of COX-2 increased at 2-hour after injury and reached the top level at 24-hour. The expression of COX-2 dropped at 48-hour after injury and returned to basal level at 72-hour. Conclusion: The expression of COX-2 could be regarded as an index of inflammation on acute trauma spinal injury. Inhibition of COX-2 might be an new therapeutic method for spinal cord injury.
