Structure and function of extracellular HMGB-1
- VernacularTitle:高迁移率族蛋白-1的结构与细胞外功能
- Author:
Nanyan JIANG
;
Wenbin YU
;
Mingquan SU
- Publication Type:Journal Article
- Keywords:
High mobility group box chromosomal protein 1;
Structure-function analysis;
Extracellular
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
HMGB-1, an ubiquitously expressed 25-KD nucleoprotein among mammals, belongs to the HMG family. Recent studies have identified that HMGB-1 is secreted by activated monocytes/macrophages via a non-classical ,vesicle-mediated secretory pathway. Extracellular HMGB-1 is an important proinflammatory cytokine. It participates in the pathogenesis of many diseases such as rheumatoid arthritis, sepsis , acute lung injury, and even leads animals death. Further studies of the mechanism and function of extracellular HMGB-1 may provide a novel strategy for the diagnosis and treatment of these diseases.
