Effects of autologous mononuclear bone marrow cells transplantation on the cardiac function and myocardial perfusion in patients with old myocardial infarction
- VernacularTitle:陈旧性前壁心肌梗死患者自体骨髓单个核细胞移植后左室心肌灌注及收缩功能的变化
- Author:
Junbo GE
;
Yanlin LI
;
Juying QIAN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Bone marrow cells;
Cardiac function
- From:
Chinese Journal of Interventional Cardiology
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of bone marrow cells(BMCs) transplantation on the improvement of cardiac function and myocardial perfusion in patients with old myocardial infarction. Methods and Results A total of 10 patients with anterior wall myocardial infarction were transplanted with autologous mononuclear BMCs through an infusion catheter which was placed with the tip in the left anterior descending coronary artery after coronary angiography and interventional therapy if necessary. After 3 months of follow-up, a significant increase of left ventricular ejection fraction(LVEF) determined by ultrasonic cardiography was found (54.5%?6.5% vs. 45.3%?9.8% before transplantation, P=0.003); 201-thallium scintigraphy (SPECT) showed that ventricular myocardial perfusion was significantly improved as the semiquantitative score of the immediate and delayed myocardial perfusion defects decreased from 29.5?5.8 and 28.6?6.3 to 23.9?5.7 and 23.0?6.1prospectively (both P
