Effects of transplanting bone marrow cells on cardiomyocyte apoptosis and expressions of Bcl-2 and Bax in post-infarction rats
- VernacularTitle:骨髓细胞移植对心肌梗死后大鼠心肌细胞凋亡及Bcl-2、Bax表达的调节
- Author:
Dongxing MA
;
Yongzhen ZHANG
;
Daoyin XIE
- Publication Type:Journal Article
- Keywords:
Cell transplantation;
Myocardial infarction;
Apoptosis
- From:
Chinese Journal of Interventional Cardiology
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the role of cardiomyocyte apoptosis in cardiac function after transplantation of bone marrow cells. Methods A mycardial infarction model was induced in SD rats by left anterior descending artery ligation. 5?106 of bone marrow mononuclear cells were injected into peri-infarct zone (BMT group). In 4 or 8 weeks post-infarct, apoptosis of cardiomyocytes and expression of Bcl-2/Bax protein were determined by TUNEL or immunohistochemistry. Cardiac function was evaluated by echocardiography (UCG). Results TUNEL results indicated that apoptosis index of peri-infarct zone from the BMT group was reduced significantly when compared with the control group (4 wk: 0.094?6?0.017 vs 0.173?0.018, P
