Study on neuronal necrosis in hippocampus of kainic acid induced status epilepticus in rats and effect of Mg ~(2+)
- VernacularTitle:海藻氨酸致癫状态大鼠海马区神经元损伤与Mg~(2+)作用的研究
- Author:
Xuewu LIU
;
Lingyi CHI
;
Shanhong CHEN
- Publication Type:Journal Article
- Keywords:
status epilepticus;
hippocampus;
Mg2+;
necrosis
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the morphology of neuronal necrosis by kainic acid(KA) induced status epilepsy (SE) in rats, and to study the brain protective effect of Mg 2+.Methods 75 adult male Wistar rats were randomly divided into KA group, Mg 2+ group and normal saline group. SE was induced with KA for 3 hours, and the rats in Mg 2+ group were intraperitoneal injected magnesium sulfate before being injected KA. 72 hours later the rats were killed. We had all rat brain sections and observe the morphology of neuronal necrosis with microscope and electron microscope.Results In KA group, seizure was induced 16.1?4.7 min after injection of KA, but seizure delayed to 25.4?6.2 min in Mg 2+ group. There was a significant difference between two groups (P
