Effect of vaproate sodium on Bax and Bcl-2 expression of hippocampus in seizures rats induced by PTZ
- VernacularTitle:丙戊酸钠对戊四氮致大鼠海马Bax和Bcl-2表达的影响
- Author:
Xianglin CHENG
;
Chengsan ZHAO
;
Hua WANG
- Publication Type:Journal Article
- Keywords:
seizure;
vaproate sodium;
pentylenetetrazole;
Bax;
Bcl-2
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of vaproate sodium (VP) on Bcl-2 and Bax expression of hippocampus in seizures rats induced by pentylenetetrazole(PTZ).Methods Twenty-four adult Wistar rats were randomly divided into normal control (NC) group, PTZ group and VAP group. A dose of PTZ [35 mg/(kg?day)] was intraperitoneally injected into the rats of PTZ group and VAP group until the kindling criterion was reached. After kindling, the rats of VAP group were administered intraperitoneally with VAP[15 mg/(kg?day)];the rats of PTZ group were administered intraperitoneally with normal saline. After 30 minutes, seizures were induced by administering PTZ intraperitoneally. The influence of VAP on Bcl-2 and Bax immmunoreactivity on hippocampus neurons was studied by immunohistochemistry method.Results Bax positive cells in hippocampus in PTZ group were more than in VAP group and NC group(all P
