Experimental study on cytotoxicity of levodopa in Parkinson's disease rat
- VernacularTitle:左旋多巴对帕金森病大鼠毒性作用的实验研究
- Author:
Jianming LU
;
Houguang ZHOU
;
Yuancheng BAO
- Publication Type:Journal Article
- Keywords:
parkinson's disease;
levodopa;
oxidative stress;
mitochondrial respiratory chain
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Levodopa on the abnormal behavior, nigral antioxidation system, mitochondrial respiration-chain function, neurotransmitter metabolism of Parkinson's disease (PD) model rat and its mechanism.Methods The rat models of PD were established through stereotaxic microinjection of 6-hydroxydopamine (6-OHDA). The rats in levodopa group were given levodopa 25 mg/(kg?d) through intragastric administration for 45 days. All the rats’behavior was tested before and after giving medicine. The activity of glutathione peroxidase(GSH-Px) and ROS, contents of malondialdedyde(MDA) and mitochondrial respiratory chain enzyme complex Ⅰ in nigra and the contents of dopamine(DA), homovanillic acid(HVA) and activity of monoamine oxidase-B(MAO-B) in caudate nucleus were assayed after treatment.Results (1) Compared with before treatment, the rotation rate after treatment decreased obviously( P
