Expression of CD147 protein in human cervical carcinoma
- VernacularTitle:CD147蛋白在人宫颈癌中的表达
- Author:
Xi ZHOU
;
Jing JI
;
Yi WU
;
Pengsheng ZHENG
- Publication Type:Journal Article
- Keywords:
CD147;
cervical carcinoma;
Western blotting;
immunohistochemical staining
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2010;31(1):14-16,25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of CD147 and its significance in human cervical carcinoma. Methods Western blotting and immunohistochemical staining were used to detect CD147 expression in cervical cancer or normal cervix uteri tissues. Results CD147 protein was expressed in all of cervical carcinomas (41/41, 100.0%) and most of normal cervix uteri tissues (11/12, 91.7%). CD147 with different molecular weights were present in cervical tissues. The percentage of CD147-positive cells and the expressional level of CD147 were higher in cervical carcinomas than in normal cervix (P<0.05). Conclusion CD147 might be recognized as a marker of cell proliferation. High expression of CD147 in cervical carcinomas suggests that it might be a potential target for cervical carcinoma therapy.
