Paroxetine for Depression in Diabetes: A Randomized Controlled Trial
- VernacularTitle:糖尿病患者伴发抑郁症的临床对照研究
- Author:
Hong XUE
- Publication Type:Journal Article
- Keywords:
psychiatry depression clinical trial diabete s Paroxetine
- From:
Chinese Mental Health Journal
2002;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Depression is prevalent in patients with diabet es It is associated with poor glycemic control and is linked to an increased r i sk for diabetic complications In this study, we assessed the efficacy of Parox e tine for depression in patients with diabetes Methods: 48 pati e nts with diabetes (type 1, n=7; type 2,n=41) and major depressive disorder enter ed an 8-week randomized placebo-controlled trial Patients were given daily dos e s of Paroxetine (up to 40 mg/day) The Beck Depression Inventory (BDI) and Hami l ton Rating Scale for Depression (HAMD) were used to measure the severity of depr ession and to determine the percentage of patients who achieved substantial impr ovement or complete remission GHb levels were obtained to monitor glycemic con t rol Results: Reduction in depression symptoms was significantl y greater in patients treated with Paroxetine compared with those receiving place bo (BDI-141 vs -89, P
