The Prevention and Therapeutic Effects of Hsp70-Antigen Peptide Complexes on B16 Tumor Pulmonary Metastasis in Mice
- VernacularTitle:Hsp70-肿瘤抗原肽复合物防治小鼠黑色素瘤B16肺转移的作用
- Author:
Hongtao CHEN
;
Guimei ZHANG
;
Hui ZHANG
;
Zuohua FENG
- Publication Type:Journal Article
- Keywords:
metastasis;
massive tumor;
metastatic foci;
heat shock protein 70
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the preventive and therapeutic effects of Hsp70-antigen peptide complexes (HACs) on pulmonary metastasis of malanoma B16 cells in mice. Methods: Antigen peptide mixtures were prepared from massive tumors and metastatic foci respctively, and bound with Hsp70 in vitro. The HACs were used to mice to prevent the formation of micrometastatic foci after the injection of B16 cells through tail vein, or treat the existent micrometastatic foci in lung The number of metastatic foci was counted and the cytotoxicity of splenocytes to B16 cells was determined. Results: After immunization with HACs, the number of metastatic foci in mice decreased significantly (P
