The Inhibition on the Proliferation of Colorectal Carcinoma Cell Strain with Different Proliferative Potential by All Trans Retinoic Acid
- VernacularTitle:全反式维甲酸对结肠癌不同增殖潜能细胞株增殖的抑制作用研究
- Author:
Ping YIN
;
Cai LI
;
Jianbo YU
;
Jindan AN
;
Xue SONG
- Publication Type:Journal Article
- Keywords:
colorectal carcinoma;
all-trans retinoic acid;
cell cycle
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The inhibition on the proliferation of colorectal carcinoma cell strain with different proliferative potential by ATRA was investigated in present study, which would benefit for the therapy of ATRA on colorectal carcinoma. Methods: The proliferation of LS174T and CW-2 colorectal carcinoma cell strain inhibited by ATRA was determined using cell observation, FACS and MTT methods. Results: The growth speed of LS174T cell strain was faster than that of CW-2. ATRA played a significant role on inhibiting the proliferation of LS174T and CW-2 cell strain and inducting the cell differetiation in vitro. Conclusions: ATRA could inhibit the growth of LS174T and CW-2 cell strain. ATRA could inhibit the proliferation of colorectal carcinoma cell and induce cell differentiation to some extent, which was correlated with the concentration of ATRA.
