The Comparation on Thl/Th2 in Pleural Effusion with That in Peripheral Blood of Patients with Advanced Lung Cancer
- VernacularTitle:晚期肺癌患者胸水及外周血Th1、Th2细胞功能的分析及意义
- Author:
Xuezhen MA
;
Yuan YAO
;
Bin WANG
- Publication Type:Journal Article
- Keywords:
advanced lung cancer, Th1, Th2 T-lymphocyte
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of helper T cells (Th1 and Th2) and its important significance in judging prognosis of patients with advanced lung cancer. Methods: Interferon-? (INF-?) and interleukin-4 (IL-4) in plasma and pleural effusion were detected by enzyme-linked immunoassay in patients with advanced lung cancer, IFN-? and IL-4 reflected activity of Thl and Th2 respectively. Results: The activity of Th1 in patients with advanced lung cancer was lower than that in normal persons in peripheral blood. For non-outstanding curative effect or progressive state of illness, the activity of Thl in patients of above 1 year survival time decreased in post-treatment than in pretreatment, the activity of Th2 increased in post-treatment. Conclusion: Activity of Helper T cells ( Th1, Th2 ) could be an important marker to diagnose lung cancer and judge prognosis in patients with advanced lung cancer.
