Heterotopic ossification
- VernacularTitle:异位骨化
- Author:
Yujiang MAO
;
Manyi WANG
;
Xinbao WU
- Publication Type:Journal Article
- Keywords:
Heterotopic ossification;
Bone scintigraphy;
NSAIDs
- From:
Chinese Journal of Orthopaedic Trauma
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
We review the literature about Heterotopic Ossification (HO) and introduce its pathophysiology, classification, incidence, clinical presentation, diagnosis, prophylaxis and treatment in this article. HO is the presence of bone in soft tissue where bone normally does not exist. Mature HO has the same morphology as callus. It is considered that 3 conditions are necessary for HO: osteogenic precursor cells, inducing agents, and a permissive environment. Fever, swelling, erythema, and occasional joint tenderness appear in the early stage of HO. The most sensitive imaging modality for early detection of HO is three-phase bone scintigraphy which can also monitor the metabolic activity and degree of maturity of HO. Non-steroidal antiinflammatory drugs (NSAIDs) are the most effective for the prophylaxis of HO after the operation of hip replacement or acetabulum fracture. Surgical resection is the only treatment for patients with severe joint tenderness following HO.