Effects of three stains on the expression of tumor necrosis fator-αlpha in carrageenan-induced synovitis in Rats
- VernacularTitle:三种他汀类药物对角叉菜胶致大鼠气囊滑膜炎组织中肿瘤坏死因子-α表达的影响
- Author:
Zheng ZHAO
;
Yanyan WANG
;
Feng HUANG
;
Jianping REN
- Publication Type:Journal Article
- Keywords:
Stains;
HE stain;
Tumor necrosis fator-alpha;
Rats
- From:
Chinese Journal of Rheumatology
2008;12(5):329-332,插2
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the anti-inflammatory mechanisms of three stains. Methods Airpouch induced acute inflammation rat model was developed by subcutaneous injection of carrageenan.Inflammatory invasion and tumor necrosis fator-alpha (TNF-α) expression levels of the inflammed skins were examined by immunohistochemical methods and digital image analysis. The anti-inflammatory action of the 3 different statins was compared. Results Stains could inhibit inflammatory invasion and the expression of TNF-α. Conclusion The statins have demonstrated strong inhibition of inflammation.
