Synergism in the cytotoxic effects of nedaplatin combined with adriamycin or mitomycin or Fluorouracil on human liver cancer cell line SMMC7721 in vitro
- VernacularTitle:奈达帕汀与其他抗癌药联用对人肝癌SMMC7721细胞株的细胞毒作用
- Author:
Longbang CHEN
;
Hong LU
;
Jing ZANG
;
Chen WANG
- Publication Type:Journal Article
- Keywords:
Human hepatocarcinoma cell;
Nedaplatin;
Adriamycin;
Mitomycin;
Fluorouracil;
Drugs interaction
- From:
Journal of Medical Postgraduates
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the suppressive effects of nedaplatin on human liver cancer cell line SMMC7721 and the interactions between nedaplatin and adriamycin or mitomycin or fluorouracil. Methods: The cytotoxic index of nedaplatin alone or combined with other chemotherapy agents on SMMC cells were detected by MTT method. Results: SMMC was sensitive to nedaplatin with a positive correlation between cytotoxic index and nedaplatin concentration. There were significant synergism in the cytotoxic effects of nedaplatin combined with adriamycin or Mitomycin or Fluorouracil on SMMC cells. Conclusion: Nedapltin is a promising agent in the treatment of human liver cancer.
