Effects of Early Intervention on Functional Outcome and NGF in Brain of Rats with Brain Damage
- VernacularTitle:早期干预对脑损伤大鼠学习记忆及神经生长因子的影响
- Author:
Jun HU
;
Qiujun LIN
;
Yanhui CHEN
- Publication Type:Journal Article
- Keywords:
physiology hypoxic-ischemic brain damage animal studies early intervention brainstem auditory evoked potential (BAEP) nerve growth factor (NGF)
- From:
Chinese Mental Health Journal
2002;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effects of early intervention on functional outcome and the repair mechanisms in rats with hypoxic-ischemic brain damage (HIBD). Methods: A HIBD rat model was established by ligating either uterine vessel of one pregnant horn. The way of intervention was the neonatal handling and enriched environment. One trial passive avoidance response, brainstem auditory evoked potential (BAEP) and NGF levels in the brain were used as assessment index. Results:(1) In the one trial passive avoidance response test, the medial step-through latency (STL) of intervention group (n=18) was much longer than that of non-intervention group (n=15) (P
