Effect of Exercise on Gene Expression of Natriuretic Peptide Receptors in the Heart
- VernacularTitle:运动对心脏心钠素受体基因表达的影响
- Author:
Shanshan PAN
;
Aiyun LU
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
exercise, natriuretic peptide receptors, gene expression, cardiac endocrine
- From:Chinese Journal of Sports Medicine
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the effect of exercise on gene expression of natriuretic peptide receptors (NPRs) in the heart, using immunofluorescent method, in situ hybridization, laser confocal scanning microscopy and the technique of computer image analysis, the distribution of NPRs in the heart and the alterations of gene expression of NPRs on the animal model of different training intensity were investigated. The result showed that NPRs located mainly in the endocardium, the sarcolemma of myocardial fiber, the connective tissue around myocardial fiber and the wall of coronary artery branch. After moderate and heavy exercise training, the gene expression of natriuretic peptide receptor-A (NPR-A) upregulated and natriuretic peptide clearance receptor (NPR-C) downregulated, whereas the gene expression of NPR-A downregulated and NPR-C upregulated after exhaustive exercise.
