Additive Therapeutic Effect of a Combination of Artemether and Daphnetin against Plasmodium berghei in Mice
- VernacularTitle:蒿甲醚与瑞香素伍用对感染伯氏疟原虫小鼠的治疗作用
- Author:
Jian GUO
;
Yichang NI
;
Jiatong WU
;
Qinmei WANG
- Publication Type:Journal Article
- Keywords:
Artemether;
Daphnetin;
P. berghei;
Drug Therapy, Combination
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of a combination of artemether and daphnetin against Plasmodium berghei ANKA strain in mice. Methods Groups of P. berghei infected mice were treated with various oral doses of artemether and daphnetin according to “4-day suppress assay”. Thin blood smears were made on the fifth day after inoculation of parasites and the parasitemia reduction rate was calculated. The ED 50 values obtained were plotted on isobolograms. A combined action of artemether and daphnetin was assessed. Results Artemether 0.4mg/(kg?d)?4d exhibited no detectable antimalarial effect, while artemether 0.4mg/(kg?d)?4d combined with daphnetin 7.7 mg/kg.d?4d showed potent antiparasile efficacy. The ED 50s of artemether in combination with daphnetin were lower than that of single artemether or daphnetin. The R-values were higher than 0.4, but lower than 2.7. Conclusion The combination of artemether with daphnetin showed an additive antiparasile effect.
