Study on the relationship between ?-fibrinogen gene-455G/A polymorphism and cerebral infarction
- VernacularTitle:?-纤维蛋白原-455G/A基因多态性与脑梗死的相关性研究
- Author:
Qinglin DONG
;
Chen ZHANG
- Publication Type:Journal Article
- Keywords:
Fibrinogen Gene polymorphism Cerebral infarction
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between ?-fibrinogen gene variation (-455G/A) and plasma fibrinogen level and cerebral infarction.Methods 86 hypertension patients with cerebral infarction(infarction group),85 hypertension patients without cerebral infarction(hypertension group) and 90 healthy people(control group) were enrolled in this trial. The polymorphism of ?-fibrinogen gene-455G/A located at the start of transcription from all subjects was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique. Plasma fibrinogen level was measured with prothrombin time (PT) assay.Results The fibrinogen level in infarction group(4.82?0.26 g/L) was significantly higher than that in control group(4.37?0.19 g/L)( P 0.05).The A-455 allele frequency in infarction group was significantly higher than those in control group and hypertension group (all P 0.05). Conclusion Plasma fibrinogen level is affected by the ?-fibrinogen gene -455G/A polymorphism. The fibrinogen A-455 allele may be an independent risk factor of cerebral infarction.
