Expression and clinical signficance of the transcription factor E26 transformation specific-1 in premature rupture of fetal membranes
- VernacularTitle:转录调节因子E26转录因子-1蛋白在胎膜早破中的表达和意义
- Author:
Jing GUO
;
Wenli GOU
;
Qing SONG
- Publication Type:Journal Article
- Keywords:
E26 transformation specific-1;
extra cellular matrix;
premature rupture of fetal membrane
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2009;30(6):735-737,765
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression and clinical significance of E26 transformation specific-1 in premature rupture of fetal membranes. Methods Fetal membranes from 75 women in the following categories were analyzed for Ets-1 expression: preterm and term premature rupture of fetal membranes; 70 women (control group) with term cesarean sections and without complications. Ets-1 protein was localized with the use of immunohistochemical S-P method. Results Ets-1 protein was expressed in both the nucleus and cytoplasm of trophoblast of human fetal membranes, with more obvious expression in the nucleus. Ets-1 protein's expression was up-regulated in the trophoblast of fetal membranes with premature rupture, which differed significantly from the control group (P<0.05). Ets-1 protein's expression was up-regulated in the trophoblast of fetal membranes with preterm premature rupture, which did not differ significantly from the control group (P>0.05). Conclusion Ets-1 is expressed in human fetal membranes and its expression is up-regulated with premature rupture of fetal membranes, suggesting a role for Ets-1 in extracellular matrix remodeling of the membranes. This study provides an evidence to predict premature rupture of fetal membrances.
