Establishment of an animal model of slow tramit constipation and the investigation of its mechanism
- VernacularTitle:慢传输型便秘模型的建立及其机制探讨
- Author:
Haichen XU
;
Lin LIN
;
Hongjie ZHANG
;
Zhiquan ZHAO
- Publication Type:Journal Article
- Keywords:
Slow transit constipation;
Animal model;
Interstitial cell of Cajal;
Morphine
- From:
Journal of Medical Postgraduates
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish an animal model of slow transit constipation and the pathobiological changes in interstitial cell of Cajal in colon. Methods:The mouse model was established by subcutaneous administration of morphine. Fecal weight was recorded daily. Transit functions of intestinal movement were examined by activated charcoal suspension pushing test and the changes of interstitial cell of Cajal were observed by immunohistochemical methods. Results:Compared with the controlled mice, there was a significant decrease in fecal weight daily(P
