Dynamic studies on the serum cytokines level of different stage in the diagnosed SARS patients
- VernacularTitle:传染性非典型肺炎患者血清细胞因子水平动态观察
- Author:
Guanghong GUO
;
Yaping TIAN
;
Yuanli MAO
;
Zhiqiang SUN
- Publication Type:Journal Article
- Keywords:
Severe acute respiratory syndrome;
SARS-CoV;
Cytokine;
Biochip
- From:
Chinese Journal of Laboratory Medicine
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical significance of the multiple cytokines in the serum of SARS patients and explore the rel ationship between the immune-reactivity and pathological damages. Methods 12 different serum cytokines have been detected in 4 groups ( inchoation, metaphase, convalescence of SARS patients and Healthy control) by using biochips technique(RANDOX) and to study the changes of each cytokine level in SARS patients. Results Compared with healthy group, IL-6 , IL-8 , IL-10 ,IFN? increased obviously and IL-1? ,IL-2,IL-4,VEGF,EGF,MCP-1, TNF?decreased obviously. Whereas IL-1?has no statistic changes among different stages of SARS. Conclusion There were obvious changes of multiple cytokines in different phase of SARS pathological process, especially in the early phase. It is further support the hypothesis that over-reaction of the immune system initiated the pathological injuries of the patients.
