A Metastatic Granulocyte Colony-Stimulating Factor Producing Sarcomatoid Carcinoma of the Lung Causing Jejunal Intussusception: Report of a Case.
10.4132/KoreanJPathol.2011.45.2.205
- Author:
Min Eui HONG
1
;
Soon Auck HONG
;
Gui Young KWON
;
Tae Jin LEE
;
Eon Sub PARK
;
Sung Jae CHA
;
Jae Hyuk DO
;
Jae Hyung YOO
Author Information
1. Department of Pathology, Chung-Ang University College of Medicine, Seoul, Korea. esp@cau.ac.kr
- Publication Type:Case Report
- Keywords:
Carcinosarcoma;
Granulocyte colony-stimulating factor;
Metastasis;
Intussusception
- MeSH:
Aged;
Antibodies, Monoclonal;
Biopsy;
Carcinosarcoma;
Granulocyte Colony-Stimulating Factor;
Granulocytes;
Humans;
Immunohistochemistry;
Intestinal Obstruction;
Intestine, Small;
Intussusception;
Keratins;
Leukocytes;
Lung;
Neoplasm Metastasis;
Neutrophils;
Thorax;
Vimentin
- From:Korean Journal of Pathology
2011;45(2):205-208
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 75-year-old man was referred to our hospital with intestinal obstruction caused by intussusception. Abdominal computed tomography (CT) revealed seven polypoid masses in the small intestine, while chest CT revealed a mass in the right lower lobe. Preoperative laboratory tests showed white blood cell (WBC) and neutrophil differential counts of 63,630/mm3 and 95%, respectively. The serum granulocyte colony-stimulating factor (G-CSF) was 114 pg/mL, which was elevated (normal range, <18.1 pg/mL). After resection of the small bowel, the WBC count decreased to 20,510/mm3. The pathology showed a poorly differentiated carcinoma with sarcomatous components confirmed by positive immunostaining of cytokeratin (AE1/AE3) and vimentin in the small intestine. Furthermore, immunohistochemistry with specific monoclonal antibodies against G-CSF was positive. A lung biopsy revealed the same histological findings as the small intestine lesion. Therefore, the patient was diagnosed as having a G-CSF producing sarcomatoid carcinoma of the lung with metastasis to the small intestine.
