Study on apolipoprotein E gene polymorphism and mtDAN4336 mutation in patients with Alzheimer's disease
- VernacularTitle:Alzheimer病患者载脂蛋白E基因多态性及线粒体DAN4336突变的研究
- Author:
Lei WANG
;
Ling YE
;
Duobin WU
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease Gene Apolipoprotein E Mitochondrial DNA
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution of Apolipoprotein E(ApoE) gene polymorphism and mtDAN*!4336 mutation in patients with sporadic Alzheimer's disease(AD),and analyse the difference of frequency of ApoE genotype from some other studies.Methods The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique was used to analyze the ApoE allele genotype and mtDAN mutation of 127 AD patients and 138 healthy elderly controls.Results In AD group, we found 2.4% of the patients with 2 ApoE4 allele gene, 18.1% of the patients with 1 ApoE4 allele gene, and 79.5% of the patients without ApoE4 allele gene. However, in control group, the frequency was 0.7%, 10.1% and 89.2% respectively. There was a significant difference between the two groups( P
