Association between variable number of tandem repeat polymorphism of endothelial nitric oxide synthase gene and cerebral infarction
- VernacularTitle:内皮细胞性一氧化氮合酶基因可变性重复序列多态性与脑梗死的关系
- Author:
Ruli GE
;
Fangmin CHEN
;
Donghui TIAN
- Publication Type:Journal Article
- Keywords:
Nitric oxide synthase Gene polymorphism Cerebral infarction
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between variable number of tandem repeat(VNTR) polymorphism of endothelial nitric oxide synthase(eNOS) gene and cerebral infarction(CI).Methods The genotypes of 152 patients with CI were detected by polymerase chain reaction(PCR) and compared with control group. Multiple regression analysis was performed to assess the independent roles of the polymorphism of eNOS and other risk factors.Results The ab genotype distribution frequency of eNOS gene in CI group(22.36%) was higher than that in control group(12.28%), and a allele frequency of eNOS gene in CI group(12.5%) was also higher than that in control group(7.0%). Both differences between CI group and control group were significant(all P
