The distribution of aquaporin-4 in brain tissue of intracerebral hemorrhagic rats
- VernacularTitle:水通道蛋白-4在脑出血大鼠脑组织的分布
- Author:
Yanhua LI
;
Shanquan SUN
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage Brain edema Aquaporin-4
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the distribution of aquaporin-4(AQP*!4) in brain tissue of intracerebral hemorrhagic rats, and its role in hemorrhagic brain edema.Methods The model of intracerebral hemorrhage(ICH) was made by infusing collagenase into rat caudate nucleuses, the immunohistochemical method was used to observe the expression of AQP*!4 in brain tissue during different time after ICH in rats.Results The expression of AQP*!4 immunoreactive positive cell bodies were observed mainly in the perihematomal brain edema zone and astrocytes of cerebral cortex, periventricular zone, supraoptic nucleus and paraventricular nucleus of ICH rats. AQP*!4 expression level elevated at 6 h and peaked at 72 h after ICH, and it was yet higher than control lever at 1 week after ICH.Conclusion AQP*!4 express increases strongly in the areas of a relevant relationship with the water metabolism. It can be concluded that AQP*!4 plays an important role in the development of brain edema after hemorrhage.
