Effect of Caspase inhibitor on apoptosis after intracerebral hemorrhage in rats
- VernacularTitle:半胱氨酸蛋白酶抑制剂对大鼠脑出血后神经元凋亡的影响
- Author:
Jun LI
;
Jiami WU
;
Zhaohu CHU
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage Apoptosis Caspase Caspase inhibitor
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of zVADfmk(a Caspase inhibitor) on Caspase-3 activation and neuronal apoptosis after intracerebral hemorrhage (ICH) in rats.Methods ICH model was made by stereotactic infusing 50?l autologous blood into the caudate nucleus. zVADfmk was given via intraventricular injection. TUNEL staining and immunohistochemitry method were used to detect the expression of apoptosis and Caspase-3 in cerebral tissues at different time point.Results After ICH, Caspase-3 and TUNEL positive cells increased obviously in the perihematomal brain edema zone compared with the pseudo-operation group ( P
