The effect of antagonist of excitatory amino acid receptor D-AP_5 on peripheral nerve regeneration
- VernacularTitle:兴奋性氨基酸受体拮抗剂D-?-氨基磷酸基戊酸对周围神经再生作用的研究
- Author:
Mei YANG
;
Shenggang SUN
;
Bo HU
- Publication Type:Journal Article
- Keywords:
Nerve regeneration Antagonist of excitatory amino acid receptor DL2-amino-5-phosphonovalerate
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of antagonist of excitatory amino acid receptor DL2-amino-5-phosphonovalerate(D-AP 5) on peripheral nerve regeneration.Methods The models of regeneration chamber after sciatic nerve injury were made by cutting 6 mm of left sciatic nerve which was connected subsequently using silicage channel. 10 ?l sterile normal saline was injected into regeneration chamber. In the treatment group, 10 ?l of different concentration of D-AP 5(2 ?mol/L used as low dosage group, 20 ?mol/L used as moderate dosage group and 200 ?mol/L used as high dosage group) was administered intrathecally while the same quantity of normal saline was used in the control group. The rats were sacrificed at 12 weeks and studied by electrophysialogy, electron microscope, microscope and image analysis.Results The nerve conduction velocity, diameter and number of regenerated myelinated nerve fiber in high dosage group were superior to those in the control group and other dosage groups(all P
