Effects of thrombolytic therapy combined with dextran sulfate in rat with cerebral embolism
- VernacularTitle:糖酐酯对脑栓塞大鼠溶栓治疗影响的研究
- Author:
Changyin YU
;
Etang TONG
;
Shenggang SUN
- Publication Type:Journal Article
- Keywords:
Dextran sulfate Thrombolytic therapy Leukocyte infiltration Apoptosis Cerebral embolism
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of dextran sulfate inhibiting leukocytes infiltration and infarct size,and apoptosis in rats with cerebral embolism.Methods Using one's blood emboli,dextran sulfate (4 mg/kg) or saline was intravenously administered after half an hour ischemia and urokinase (5000 U/kg) was injected after 2h or 4h ischemia in rat embolic stroke models.At 12h or 24h after ischemia,the infarct size were measured by TTC staining.ICAM-1 expression and leukocytes infiltration were evaluated by immunohistochemistry, apoptosis were detected by TUNEL;blood-brain barrier(BBB) and cell necrosis were observed by electromicroscopy.Results combined thrombolytic group compared with pure thrombolytic group,the infarct focus decreased(P
