Studies on correlation among genetic polymorphism of glutathione S-transferases and serum creatinine levels in end stage renal disease patients
- VernacularTitle:终末期肾病患者谷胱甘肽转移酶基因多态性与血肌酐水平的相关性研究
- Author:
Tao MA
;
Weimin CAI
;
Bing CHEN
;
Weixin HU
;
Yan ZHOU
;
Hongq REN
- Publication Type:Journal Article
- Keywords:
Glutathione S-transferase;
Genetic polymorphism;
End stage renal disease
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the correlation among genetic polymorphism of glutathione S-transferases (GST) T1, M1 and serum creatinine levels,as well as intact parathyroid hormone (PTH) levels in the end stage of renal disease(ESRD). Methods: 118 blood samples of ESRD and 133 of healthy control had been enrolled, and simultaneously the patients' serum creatinine (SCr), blood uria nitrogen (BUN), serum calcium and serum phosphorus were recorded. Polymerase chain reaction (PCR) had been employed to determine the genotypes of GST and immunoradiometric assay was used to determine PTH levels. Results: The distribution frequencies of dual null GST T1 and M1(A), null GST T1 and functional M1 (B), functional T1 and null GST M1(C) and dual functional GST T1 and M1(D) were 16.9%, 11.0%, 44.9%, 27.1% in ESRD and 14.4%, 10.8%, 46.7%, 28.1% in the healthy control, respectively. There was no difference between the two groups (P=0.945); Mean SCr levels of A was higher than that of B (P=0.047) and C (P=0.007) group in ESRD. Conclusion: Distributions of GST Genotypes had no difference among ESRD and healthy control groups; SCr level of dual null GST T1 and M1 (A) was higher than single null GST (B and C) in ESRD. GST may played some roles in metabolism of poisons and protecting cells from the attack of toxic substances.
