Advantage and limitation of intranasal drug delivery for systemic diseases
- VernacularTitle:经鼻腔用药治疗全身性疾病的潜在优势和局限性
- Author:
Xiangrong CHENG
;
Qiuping WANG
- Publication Type:Journal Article
- Keywords:
Nasal drug delivery;
Physiology of the nose;
Drug
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The nasal route is one of the most permeable and highly vascularized site for ensuring rapid drug absorption and onset of therapeutic action. It has been potentially explored as an alternative route for delivery of drugs with poor bioavailability and for the biosensitive and high molecular weight compounds such as proteins, peptides, steroids, vaccines,etc. In this review nasal drug delivery approach and its limitations, some factors influencing drug absorption,mucoadhesion, and the safety of nasal mucoadhesive drug delivery systems as well were discussed.
