Effect of Sertraline in Treatment of Dysthymia
- VernacularTitle:舍曲林治疗心境恶劣的疗效观察
- Author:
Jiancheng LIU
;
Yuhua CUI
;
Wentian DONG
- Publication Type:Journal Article
- Keywords:
psychiatry dysthymia RCT effect Sertraline
- From:
Chinese Mental Health Journal
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical effect of Sertraline in treatment of dysthymia. Methods:63 outpatients diagnosed as dysthymia according to ICD-10 were randomly assigned to study group (n=33) and placebo group. Randomized double blind control study was done for 8 weeks with Sertraline from 50-200 mg/d. HAMA and HAMD were used to assess the effect.Results:At the end of 8 weeks, 54 patients completed the trial. Patients of both groups had lower HAMD scores than baseline from 2 weeks, and this trend continued through the 8 weeks observation. During this period, HAMD score of the study group declined more significantly than that of the placebo group. At the end of 8 weeks, the score of HAMA of the study group was also lower than that of the placebo group. The side effects of Sertraline were mild.Conclusion:Sertraline is effective in treatment of psychiatric outpatients with dysthymia.
