Effects of PSS on ET-1 secretion and platelet functions in the patients with early diabetic nephropathy
- VernacularTitle:藻酸双酯钠对早期糖尿病肾病血浆内皮素和血小板功能的影响
- Author:
Sheng YANG
- Publication Type:Journal Article
- Keywords:
polysaccharide sulfate (PSS);
diabetic nephropathy(DN);
Endothelin-1 (ET-1);
blood lipid;
hemorrheology
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects and mechanism of action of PSS on the treatment of patients with early DN. Methods 76 patients with early DN were given PSS 100mg(iv gtt, qd) for 14 days. ET-1, TXB_2, 6-Keto-PGF_(1a), blood viscosity TG, TC, HDL-C, LDL-C and urine protein quantity(24h UPQ) were determined and compared between before and after treatment. Results All indexes above were improved significantly after therapy. Conclusion PSS may modulate ET-1 secretion and the ratio of TXB_2/6-Keto-PGF_(1a), reduce blood lipid content and viscosity, improve hemorrheology in patients with early DN.
