Progress of research on predicting breast cancer prognosis based on multi-gene expression levels
10.3969/j.issn.1000-8179.2013.13.015
- VernacularTitle:基于多基因表达水平的乳腺癌预后预测研究进展*
- Author:
Xiaoqing LI
;
Yumei FENG
- Publication Type:Journal Article
- Keywords:
breast cancer;
prognosis;
microarray;
qRT-PCR
- From:
Chinese Journal of Clinical Oncology
2013;(13):807-810,814
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is one of the most common cancers in women. Current clinical prognostic indicators and practice guide-lines show that almost 70% of node-negative and 30% of lymph node-positive breast cancer patients can survive 5-10 years without dis-tant metastasis after surgery. Patients also unnecessarily suffer the side effects of chemotherapy. Assays on multi-gene expression levels as prognosis prediction indicators have been successfully used to predict the prognosis of breast cancer patients because of the abnor-mal expression levels of a series of metastasis-related genes in cancer cells with high metastatic potential. In this review, we highlight the progress of research on predicting breast cancer prognosis based on multi-gene expression levels detected by microarray and qRT-PCR methods.
