The changes and significance of molecular markers of prethrombotic state in coronary artery patients with diabetes mellitus undergoing coronary angioplasty
- VernacularTitle:冠心病合并糖尿病患者冠状动脉介入术前后血栓形成前状态分子标志物的变化
- Author:
Jianlin MA
;
Xinming LI
;
Zhetan SU
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Diabetes mellitus;
Angioplasty, transluminal, percutaneous coronary;
Prethrombotic State;
Molecular markers
- From:
Chinese Journal of Interventional Cardiology
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of molecular markers of prethrombotic state (PTS) in coronary artery disease (CAD) patients with diabetes mellitus (DM) undergoing coronary agioplasty. Methods Thirty-two patients with CAD (group A) and twenty-four CAD patients with noninsulin-dependent diabetes mellitus (NIDDM) (group B) were chosen as objects undergoing coronary agioplasty, and molecular markers of PTS, lipid peroxide (LPO), endothelial function were measured before and 20 minutes, 24 hours, and 7 days after the opration respectively. Results There were significant changes of molecular markers of PTS, LPO, and endothelial function in both groups after the opration, but the changes were even more pronounced in group B. It was on the 7th day that there were still the changes in group B, whereas the changes were prone to the levels of pre-opration in group A. Conclusion There was a series of significant changes of molecular markers of PTS, LPO, and endothelial function in CAD patients after the angioplasty, and the changes were even more pronounced in those with DM.
