Experimental study of effect on abciximab on endothelin function of injured artery
- VernacularTitle:Abciximab对动脉损伤后血清一氧化氮和内皮素水平的影响
- Author:
Zhitao TENG
;
Shanglang CAI
;
Jinshan WO
- Publication Type:Journal Article
- Keywords:
Endothelium, vascular;
Abciximab;
Thrombosis
- From:
Chinese Journal of Interventional Cardiology
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of abciximab on endothelin function of injured artery.Methods Fifty-four rats were divided randomly into artificial group, control group and abciximab group (n=18). We made ballon endothelium denud-ation in abdominal aorta of rats in the latter two groups. The abciximab were injected in abciximab group (0.25 mg/kg). Six rats were respectively killed 1 week, 2 weeks, 4 weeks after operation in each group. Nitric oxide (NO) and endothelium (ET) were obtained before killing. Results NO and ET in abciximab group were lower than in artificial group, control group 4 weeks later. Conclusion Abciximab can improve artery endothelin function after artery injury.
